In comprehensive studies published recently in the journal Foods, it was reported that the long-term addition of grapes to the diet of mice leads to unique gene expression patterns, reduces fatty liver, and extends the lifespan of animals consuming a high-fat western style diet. The research team was led by Dr. John Pezzuto of Western New England University.
Pezzuto, who is an author of over 600 papers in the scientific literature, said he was especially amazed by these results. “We have all heard the saying ‘you are what you eat’ which is obviously true since we all start out as a fetus and end up being an adult by eating food. But these studies add an entirely new dimension to that old saying. Not only is food converted to our body parts, but as shown by our work with dietary grapes, it actually changes our genetic expression. That is truly remarkable.”
What is the effect of this alteration of gene expression? As shown in this paper, fatty liver is prevented or delayed. Fatty liver is a condition that affects around 25% of the world’s population and can eventually lead to untoward effects, including liver cancer. The genes responsible for the development of fatty liver were altered in a beneficial way by consuming grapes. In ancillary work, not only is the expression of genes altered, but metabolism is also changed by dietary grapes. This study was recently published by a collaborative team led by Dr. Jeffrey Idle in the journal Food & Function.
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